Researchers have discovered that CO2 helps extend the longevity of hyaluronic acid (HA) fillers. Giuseppe Nisi, M.D., and colleagues compared the efficacy, tolerability, and effect duration of HA fillers with and without the addition of CO2 therapy for the cosmetic correction of nasolabial folds. They enrolled 40 healthy women who received a split-face, blinded, and randomized treatment for their nasolabial folds: The subjects received only HA filler only in one fold, and filler plus subcutaneous injections of CO2 in the other. Two blinded plastic surgeons evaluated the results after the procedures at one week, four months, and six months using a 1-5 graduated scale (GAIS). Each patient was also asked to express her opinion about the cosmetic result at that time.
All patients experienced better results on the side treated with CO2 therapy plus HA, according to the blinded evaluation at four and six months. At the six-month follow-up, patients treated with HA plus CO2 therapy had maintained their results, while the nasolabial fold treated only with filler had returned to baseline. The results suggest that the CO2 extends the longevity of HA fillers. The findings were published in the Journal of Cosmetic Dermatology in June.