Clear Health, a telehealth platform for personalized, at-home skincare, recently launched Isoclear, a prescription topical acne treatment built around isotretinoin, the same active ingredient used in oral Accutane, delivered through a multi-phase regimen. Isoclear takes one of dermatology’s most well-known molecules and reimagines it in a topical format, combining clinically proven ingredients into customized, prescription formulations delivered through a digital-first experience. “Oral isotretinoin is highly effective, but it’s not the right fit for every patient," says Michael Chang, CEO and co-founder of Clear Health. "Isoclear expands access to this gold-standard molecule in a way that’s more flexible, personalized, and aligned with how patients want to receive care today.”
How it works: Clear Health patients are connected with licensed dermatologists who prescribe personalized formulations and oversee care through a streamlined digital experience. All treatments are prescription-only and fulfilled by licensed pharmacies based on an individual provider’s plan, with formulations adjusted over time as the patient’s skin improves. Many patients see results within several weeks. Isoclear is available for $50 per month, billed as $100 for a two-month supply. Patients can also choose an annual plan for $40 per month, billed at $480 annually. Three-month supply and billing options are available during the Fade and Renew phases of treatment.
Phase 1 – CLEAR (Active Acne Treatment)
Targets breakouts at the source by reducing clogged pores, bacteria, and inflammation
- Topical isotretinoin normalizes skin cell turnover and prevents clogged pores
- Topical clindamycin reduces acne-causing bacteria and inflammation (patients will experience short-term exposure to reduce antibiotic resistance)
- Additional supporting ingredients may be included based on patient needs
Phase 2 – FADE (Post-Acne Repair)
Focuses on improving discoloration and restoring even skin tone following breakouts
- Topical isotretinoin continues to support cell turnover
- Tranexamic acid helps reduce hyperpigmentation and dark spots
- Niacinamide (Vitamin B3) supports the skin barrier and reduces redness
Phase 3 – RENEW (Maintenance & Skin Quality)
Supports long-term skin health, texture, and overall appearance
- Topical isotretinoin maintains clear pores and ongoing renewal
- Copper peptide (GHK-Cu) supports skin repair and improves texture and firmness