A new study published in the journal Dermatologic Surgery this month revealed that hyaluronic acid (HA) fillers provide sustained dermal remodeling and stimulate collagen production. The researchers found HA filler injections provide sustained clinical results and a measured increase in collagen in the small group of 40-year-old women studied. Each received HA filler injections in the nasolabial folds and preauricular regions of the face. Skin biopsies of the preauricular regions were performed prior to treatment and at three and nine months after the procedure. The 16 patients who completed the study had demonstrated improvement 12 months after treatment. Morphologic evaluation showed increases in the epidermal layers and a statistically significant increase in collagen fibers at three and nine months after the initial procedure. Researchers, including Fabiana Braga, M.D., noted the results are explained by the presence of HA gel on the dermis and by the dermal remodeling induced by the HA filler injected under the surface. This is good news for fillers that incorporate hyaluronic acid, including Captique, Esthélis, Elevess, Hylaform, Juvéderm, Perlane, Prevelle, Puragen, Restylane, and more. The study is a significant breakthrough as it shows the benefits of HA fillers are not limited to the short-term wrinkle reduction.